A computationally efficient framework for the simulation of cardiac perfusion using a multi-compartment Darcy porous-media flow model (pages 217–232)
C. Michler, A. N. Cookson, R. Chabiniok, E. Hyde, J. Lee, M. Sinclair, T. Sochi, A. Goyal, G. Vigueras, D. A. Nordsletten and N. P Smith
Version of Record online: 18 OCT 2012 | DOI: 10.1002/cnm.2520
We present a method to efficiently simulate coronary perfusion within clinically relevant time frames and demonstrate this on a subject-specific model of the left ventricle with geometry, inflow rates and source locations derived from experimental data. Perfusion is modeled as a multicompartment Darcy porous-media flow, where each compartment encapsulates the spatial scales of the vascular network in a certain range. Reducing the N-compartment system of Darcy equations to N pressure equations and N subsequent projection problems to recover the Darcy velocity significantly enhances computational efficiency.