International Journal for Numerical Methods in Biomedical Engineering

Cover image for Vol. 29 Issue 3

March 2013

Volume 29, Issue 3

Pages 309–443

  1. Research Articles

    1. Top of page
    2. Research Articles
    1. Coupled finite difference and boundary element methods for fluid flow through a vessel with multibranches in tumours (pages 309–331)

      Qiang Sun and Guo Xiong Wu

      Article first published online: 5 JUL 2012 | DOI: 10.1002/cnm.2502

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      A 3D computational model is developed for a complicated permeable vessel with multibranches and curvature embedded in tumour interstitium. This model and the numerical procedure by the coupled finite difference method and boundary element method are used to investigate how complex tumour vascular structures affect the tumour flow field, which has strong influence on the delivery of anticancer agents. This work is a significant step forward towards the goal of better understanding of flow in a network of vessels in tumours.

    2. Augmented Lagrange methods for quasi-incompressible materials—Applications to soft biological tissue (pages 332–350)

      S. Brinkhues, A. Klawonn, O. Rheinbach and J. Schröder

      Article first published online: 2 AUG 2012 | DOI: 10.1002/cnm.2504

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      The energy functions used to describe quasi-incompressible arterial tissue typically incorporate a penalty function. Because the penalty function will affect the conditioning of the stiffness matrices, the performance of iterative solvers will degrade and the quality of the solutions of the direct solver will deteriorate for high penalty parameters. It will be shown that, with the use of an augmented Lagrange approach, the arising linear systems of equations have better properties and the convergence of the iterative solver is improved.

    3. Influence of bypass angles on extracardiac Fontan connections: a numerical study (pages 351–362)

      Jinli Ding, Youjun Liu and Feng Wang

      Article first published online: 25 AUG 2012 | DOI: 10.1002/cnm.2508

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      For the treatment of the congenital single ventricle heart defects, hepatic artery blood distribution to two lungs and energy dissipation are sensitive to the bypass angles when placing the extracardiac Fontan connections. An appropriate increase in the angle between the inferior vena cava and right pulmonary artery or that between the inferior vena cava and superior vena cava may lead to optimal options.

    4. Reduction of the impact of multiple uncertain conductivity values on EEG dipole source analysis (pages 363–379)

      B. R. Yitembe, G. Crevecoeur, R. Van Keer and L. Dupré

      Article first published online: 29 SEP 2012 | DOI: 10.1002/cnm.2510

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      A methodology is presented to reduce the impact of multiple uncertain conductivity values on dipole localization when solving the EEG inverse problem. A cost function and strategies for selecting the potential values when solving the inverse problem are proposed to deal with multiple uncertainties

    5. A system for individualized prosthetic modeling of the femoral head (pages 380–391)

      Bin Liu, Zhihuan Huang, Xianyong Jia and Zongge Yue

      Article first published online: 10 SEP 2012 | DOI: 10.1002/cnm.2512

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      To obtain the optimal model of the femoral head prosthesis for the target sufferer, in this paper, an individualized modeling system is introduced. The necrotic femoral heads can be recovered into the satisfactory models by this system, which can provide a theoretical model for the accurate operation position fixing in the orthopedic clinic and an innovative practical means for the individualized modeling of the artificial femoral head prosthesis.

    6. Biomechanical responses of a pig head under blast loading: a computational simulation (pages 392–407)

      Feng Zhu, Paul Skelton, Cliff C. Chou, Haojie Mao, King H. Yang and Albert I. King

      Article first published online: 29 SEP 2012 | DOI: 10.1002/cnm.2518

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      Finite element modeling was conducted to simulate the shock wave generation, propagation and application on a pig head under a shock tube environment. Anatomical details and appropriate tissue properties have been included in the numerical pig head model, and the regional effect of pressure was studied after the numerical models were validated. Pressure enhancement was found in the skull, which is believed caused by shock wave reflection at the interface of the materials with distinct wave impedances.

    7. A black-box decomposition approach for coupling heterogeneous components in hemodynamics simulations (pages 408–427)

      Pablo J. Blanco, Jorge S. Leiva and Gustavo C. Buscaglia

      Article first published online: 6 NOV 2012 | DOI: 10.1002/cnm.2519

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      A flexible decomposition approach is proposed to coupling heterogeneous models in computational hemodynamics. The Broyden method is used to solve the associated system of nonlinear interface equations. A multiple time-step algorithmic approach is proposed to deal with different model requirements. The strategy is employed to simulate the blood flow in a 3D-1D-0D closed-loop model of the cardiovascular system.

    8. Numerical investigation of axonal cargo rerouting in a dendrite: A three kinetic state model (pages 428–443)

      A. V. Kuznetsov

      Article first published online: 18 OCT 2012 | DOI: 10.1002/cnm.2521

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      A three-kinetic state model of axonal cargo rerouting in a dendrite is developed. It is assumed that axonal cargos are transported by kinesin motors; they can enter dendrites riding on plus-end-out microtubules (MTs); cargos are rerouted by dissociating from these MTs and associating with minus-end-out MTs. The model predicts how far axonal cargos can penetrate into the dendrite, concentrations of various populations of axonal cargos, and cargo fluxes.

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