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International Journal for Numerical Methods in Biomedical Engineering

Cover image for Vol. 30 Issue 1

January 2014

Volume 30, Issue 1

Pages 1–142

  1. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    4. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    5. Research Articles
    6. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    7. Research Articles
    1. You have full text access to this OnlineOpen article
      Mathematical modeling of postmenopausal osteoporosis and its treatment by the anti-catabolic drug denosumab (pages 1–27)

      S. Scheiner, P. Pivonka, D. W. Smith, C. R. Dunstan and C. Hellmich

      Article first published online: 30 AUG 2013 | DOI: 10.1002/cnm.2584

      Thumbnail image of graphical abstract

      A pharmacokinetics model of the anti-catabolic drug denosumab is combined with an integrated systems biology/multiscale bone mechanics model of bone remodeling for the purpose of studying the disease progress of postmenopausal osteoporosis, with and without taking into account drug intervention by means of denosumab. The thereby obtained model predictions agree well with corresponding biomarker measurements. The results presented here also motivate to invest in explicit modeling of the secondary bone mineralization process and its linkage to RANKL and osteocytic actions.

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      Bone remodelling in the natural acetabulum is influenced by muscle force-induced bone stress (pages 28–41)

      Justin Fernandez, Massimo Sartori, David Lloyd, Jacob Munro and Vickie Shim

      Article first published online: 25 AUG 2013 | DOI: 10.1002/cnm.2586

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      An Instron-validated hip model integrated with electromyography-estimated muscle forces is used to evaluate acetabular stress patterns in the natural hip. Muscle forces primarily reduced peak stress in the pelvis compared with applying a net force through the femur. Muscle forces also increased stress where large muscles have small insertion sites. This has implications for the pelvis where bone stress and strain are key excitation variables used to initiate bone remodelling.

  2. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    4. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    5. Research Articles
    6. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    7. Research Articles
    1. You have free access to this content
      Analysis of Red Blood Cell Deformation under Fast Shear Flow for Better Estimation of Hemolysis (pages 42–54)

      Masanori Nakamura, Sadao Bessho and Shigeo Wada

      Article first published online: 15 AUG 2013 | DOI: 10.1002/cnm.2587

      Thumbnail image of graphical abstract

      The study is aimed to determine whether the extent of red blood cell (RBC) deformation is correlated with the shear stress used as a hemolysis index. The RBC deformation was assessed by the maximum first principal strain. Although the results were consistent under steady Couette flow, this was not the case under unsteady Couette flow or stenosed flow. These results suggest that there is a limitation in accurately estimating the mechanical damage of RBCs solely from a macroscopic flow field.

  3. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    4. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    5. Research Articles
    6. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    7. Research Articles
    1. You have free access to this content
      Derivation of aortic distensibility and pulse wave velocity by image registration with a physics-based regularisation term (pages 55–68)

      David C. Barber, Isra Valverde, Yubing Shi, Alistair Brown, Philipp Beerbaum and D. Rodney Hose

      Article first published online: 10 OCT 2013 | DOI: 10.1002/cnm.2589

      Thumbnail image of graphical abstract

      Reliable estimates of aortic distensibility and pulse wave velocity and their variation along the axis of the vessel can be derived by registration of time series images using a regularisation term based on the one-dimensional wave equation. Validation is from numerical phantom data, and results are presented from clinical images for six cases of mild aortic coarctation.

  4. Research Articles

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    4. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    5. Research Articles
    6. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    7. Research Articles
    1. You have free access to this content
      Computational modeling of human head under blast in confined and open spaces: primary blast injury (pages 69–82)

      A. Rezaei, M. Salimi Jazi and G. Karami

      Article first published online: 28 AUG 2013 | DOI: 10.1002/cnm.2590

      Thumbnail image of graphical abstract

      This paper is a computational study of traumatic brain injury (TBI) when a human head model is exposed to blast scenarios in three different spaces: open, semi-confined, and fully confined. TBI is investigated to address the effects of confinement on primary blast injuries (PBI) in terms of injury-related biomechanical parameters of acceleration, intracranial pressure, and shear stress. The results show that the reflected blast waves from the walls increase the risk of PBI.

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      A multiscale SPH particle model of the near-wall dynamics of leukocytes in flow (pages 83–102)

      Babak Gholami, Andrew Comerford and Marco Ellero

      Article first published online: 5 SEP 2013 | DOI: 10.1002/cnm.2591

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      An efficient multiscale Lagrangian particle solver based on SPH is developed for modeling of leukocyte dynamics in large arteries. Because of large separation of space/time scales in transport of leukocytes in blood, the computational domain is divided into bulk and near-wall subregions, and each is handled separately. Consistency of the proposed model is guaranteed through coupling of quantities at the interface of the subregions. Our approach brings considerable gain in computational costs associated with simulation of blood-borne particles. This has been demonstrated in a backward-facing step geometry, which possesses many complex flow features present in target in vivo applications.

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      Simulation of nanoparticle transport in airways using Petrov–Galerkin finite element methods (pages 103–116)

      Prathish Rajaraman and Jeffrey J. Heys

      Article first published online: 25 AUG 2013 | DOI: 10.1002/cnm.2592

      Thumbnail image of graphical abstract

      When modeling nanoparticle transport and deposition in the human airways, the standard finite element method becomes unstable, and, in order resolve this issue, various stabilization methods were considered for their accuracy and computational cost. Two test problems were used for comparing the stabilization approaches: the Graetz problem and flow through multiple generations of a human airway geometry. The optimal stabilization method depended upon the particle size and geometry, but, for most problems consider, the Graetz problem was the optimal choice.

  5. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    4. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    5. Research Articles
    6. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    7. Research Articles
    1. You have full text access to this OnlineOpen article
      Toward GPGPU accelerated human electromechanical cardiac simulations (pages 117–134)

      Guillermo Vigueras, Ishani Roy, Andrew Cookson, Jack Lee, Nicolas Smith and David Nordsletten

      Article first published online: 20 SEP 2013 | DOI: 10.1002/cnm.2593

      Thumbnail image of graphical abstract

      The paper attached is, to the authors knowledge, the first attempt at accelerating cardiac mechanic using the GPU and linking this weakly coupled electromechanics to GPU accelerated electrophysiology. Using a re-use strategy, which minimizes the linear solves required, the computational expense of simulating mechanics depends strongly on the evaluation of residual. By accelerating this portion of the solve on the GPU, the mechanics solve can be seen to improve significantly. Further results are presented, which verify the effectiveness of GPU computations for electrophysiology.

  6. Research Articles

    1. Top of page
    2. Paper Presented at ECCOMAS-3MBM - Multiscale and multiphysics modelling in bone mechanobiology
    3. Paper Presented at WCCM 2012 - 10th World Congress on Computational Mechanics
    4. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    5. Research Articles
    6. Special Issue Paper - Numerical Methods and Applications of Multi-Physics in Biomechanical Modeling
    7. Research Articles
    1. You have free access to this content
      Effects of changing physiologic conditions on the in vivo quantification of hemodynamic variables in cerebral aneurysms treated with flow diverting devices (pages 135–142)

      Fernando Mut, Danny Ruijters, Drazenko Babic, Carlos Bleise, Pedro Lylyk and Juan R. Cebral

      Article first published online: 30 AUG 2013 | DOI: 10.1002/cnm.2594

      Thumbnail image of graphical abstract

      Quantification aneurysmal hemodynamic environment and its change after deployment of flow diverting devices is important to assess their efficacy and understand their long-term effects. In this study, we estimated deviations in the quantification of hemodynamic alterations during flow diversion treatment of cerebral aneurysms due to changing physiologic flow conditions. Variations in the inflow conditions during the procedure may induce important deviations in the quantification of these changes.

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