Modelling the influence of endothelial heterogeneity on the progression of arterial disease: application to abdominal aortic aneurysm evolution (pages 563–586)
P. Aparício, A. Mandaltsi, J. Boamah, H. Chen, A. Selimovic, M. Bratby, R. Uberoi, Y. Ventikos and P.N. Watton
Version of Record online: 14 JAN 2014 | DOI: 10.1002/cnm.2620
We sophisticate a fluid–solid growth computational framework for modelling aneurysm evolution. Degradation of elastin is driven by reductions in wall shear stress (WSS) below homeostatic thresholds. Collagen growth and remodelling are linked to the cyclic deformation of the arterial wall. Homeostatic WSS thresholds are modelled as follows: (i) constant; (ii) spatially heterogeneous; and (iii) spatially and temporally heterogeneous. We examine how the definition of the WSS homeostatic threshold influences a model of abdominal aortic aneurysm evolution.