The effect of disorder on pinning and wetting models has attracted much attention in theoretical physics. In particular, it has been predicted on the basis of the Harris criterion that disorder is relevant (annealed and quenched models have different critical points and critical exponents) if the return probability exponent α, a positive number that characterizes the model, is larger than ½. Weak disorder has been predicted to be irrelevant (i.e., coinciding critical points and exponents) if α < ½. Recent mathematical work has put these predictions on firm ground. In renormalization group terms, the case α = ½ is a marginal case, and there is no agreement in the literature as to whether one should expect disorder relevance or irrelevance at marginality. The question is also particularly intriguing because the case α = ½ includes the classical models of two-dimensional wetting of a rough substrate, of pinning of directed polymers on a defect line in dimension (3 + 1) or (1 + 1), and of pinning of an heteropolymer by a point potential in three-dimensional space. Here we prove disorder relevance both for the general α = ½ pinning model and for the hierarchical pinning model proposed by Derrida, Hakim, and Vannimenus, in the sense that we prove a shift of the quenched critical point with respect to the annealed one. In both cases we work with Gaussian disorder and we show that the shift is at least of order exp(−1/β4) for β small, if β2 is the disorder variance. © 2009 Wiley Periodicals, Inc.