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Correlated Movement and Bending of Nucleic Acid Structures Visualized by Multicolor Single-Molecule Spectroscopy



At the end of the rainbow… The structure and dynamics of three- and four- way DNA junctions are studied using triple alternating laser excitation. Steroid binding distorts the structure of three-way junctions with correlated bending of all branches towards a steeper pyramid (see picture). In four-way junctions, the dynamics of three distances are visualized simultaneously.

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