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SERS Chiral Recognition and Quantification of Enantiomers through Cyclodextrin Supramolecular Complexation

Authors

  • Sara Abalde-Cela,

    1. Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo (Spain), Fax: (+34) 986 818617
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  • Dr. José M. Hermida-Ramón,

    1. Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo (Spain), Fax: (+34) 986 818617
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  • Dr. Pablo Contreras-Carballada,

    1. Photonics Group, HIMS, Universiteit van Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam (The Netherlands)
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  • Prof. Luisa De Cola,

    1. Physikalisches Institut, Westfälische Wilhelms-Universität, Mendelstrasse 7, 48149 Münster (Germany)
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  • Dr. Andrés Guerrero-Martínez,

    Corresponding author
    1. Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo (Spain), Fax: (+34) 986 818617
    • Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo (Spain), Fax: (+34) 986 818617
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  • Dr. Ramón A. Alvarez-Puebla,

    Corresponding author
    1. Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo (Spain), Fax: (+34) 986 818617
    • Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo (Spain), Fax: (+34) 986 818617
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  • Prof. Luis M. Liz-Marzán

    1. Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo (Spain), Fax: (+34) 986 818617
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  • SERS: Surface-Enhanced Raman Scattering

Abstract

We introduce here a simple approach in which a cyclodextrin, functionalized with thiols in the narrower rim, is assembled onto the silver surface of a SERS platform composed of polystyrene beads coated with silver nanoparticles. Trapping properties of the fabricated sensor are demonstrated through the retention of different enantiomers (R,R or/and S,S) of hydrobenzoin (HBZ), a molecule that has not been reported before in SERS because it has no affinity for coinage metal surfaces. Further, selective recognition of each enantiomer and semiquantification of its proportion in a racemic mixture are provided by the analysis of the SERS spectra of the HBZ–cyclodextrin complex, in full agreement with the surface selection rules.

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