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Keywords:

  • α-synuclein;
  • FlAsH;
  • FRET;
  • Parkinson′s disease;
  • quantum dots
Thumbnail image of graphical abstract

A FRET formalism in terms of the ratio between the rate constants for deactivation of the donor excited state by resonance energy transfer (kt) and by emission (kf) is introduced (see picture). The advantages of the approach are illustrated by FRET imaging of the donor/acceptor system consisting of co-aggregates of the amyloid protein alpha-synuclein labeled with the biarsenical FlAsH and quantum dots (605 nm) functionalized with alpha-synuclein.