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Keywords:

  • chirality;
  • circular dichroism;
  • conformation;
  • lanthanides;
  • MRI contrast agents

Abstract

Ln DOTA derivatives (DOTA=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) are known to undergo relevant stereoisomeric equilibria in solution, which greatly modulate their chemical as well as their magnetic and optical properties. The subject is reviewed in terms of classical stereochemical description, with reference to conformational enthalpies. Yb is taken as the reference element because of its unique spectroscopic properties, namely, a small contact contribution to the paramagnetic shift and an intense near-infrared electronic circular dichroism, endowed with an easily recognizable fine structure.