The Rate-Determining Step is Dead. Long Live the Rate-Determining State!
Article first published online: 27 APR 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: Jacobus van't Hoff
Volume 12, Issue 8, pages 1413–1418, June 6, 2011
How to Cite
Kozuch, S. and Martin, J. M. L. (2011), The Rate-Determining Step is Dead. Long Live the Rate-Determining State!. ChemPhysChem, 12: 1413–1418. doi: 10.1002/cphc.201100137
- Issue published online: 24 MAY 2011
- Article first published online: 27 APR 2011
- Manuscript Received: 18 FEB 2011
- rate-determining step;
- reaction mechanisms;
- transition-state theory
The concept of a rate-determining step (RD-Step) is central to the kinetics community, and it is basic knowledge even for the undergraduate chemical student. In spite of this, too many different definitions of the RD-Step appear in the literature, all of them with drawbacks. This dilemma has been thoroughly studied by several authors in the attempt to “patch” the drawbacks and bring the RD-Step to a correct physical meaning. Herein we review with simple models the most notable definitions and some challengers of the RD-Step concept, to conclude with the deduction that there are no rate-determining steps, only rate-determining states.