Communication

Sub-Diffraction Imaging of Huntingtin Protein Aggregates by Fluorescence Blink-Microscopy and Atomic Force Microscopy

  1. Whitney C. Duim1,
  2. Bryan Chen2,
  3. Prof. Judith Frydman2,
  4. Prof. W. E. Moerner1,*

Article first published online: 6 JUL 2011

DOI: 10.1002/cphc.201100392

Issue

ChemPhysChem

ChemPhysChem

Volume 12, Issue 13, pages 2387–2390, September 12, 2011

Additional Information

How to Cite

Duim, W. C., Chen, B., Frydman, J. and Moerner, W. E. (2011), Sub-Diffraction Imaging of Huntingtin Protein Aggregates by Fluorescence Blink-Microscopy and Atomic Force Microscopy. ChemPhysChem, 12: 2387–2390. doi: 10.1002/cphc.201100392

Author Information

  1. 1

    Department of Chemistry, Stanford University, 375 North-South Axis, Stanford, CA 94305 (USA), Fax: (+1) 650-725-0259

  2. 2

    Department of Biology,Stanford University, Clark Center E200, 318 Campus Drive, Stanford, CA, 94305 (USA)

*Department of Chemistry, Stanford University, 375 North-South Axis, Stanford, CA 94305 (USA), Fax: (+1) 650-725-0259

Publication History

  1. Issue published online: 6 SEP 2011
  2. Article first published online: 6 JUL 2011
  3. Manuscript Received: 21 MAY 2011

Funded by

  • Unknown funding agency. Grant Number: PN2EY016525
  • National Eye Institute of the U.S. National Institutes of Health
  • National Science Foundation

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Keywords:

  • aggregation;
  • proteins;
  • scanning probe microscopy;
  • single-molecule studies;
  • super-resolution
Thumbnail image of graphical abstract

Resolving aggregates: Single-molecule super-resolution imaging of fluorescent Huntington′s disease proteins reveals the detailed morphology of aggregates in aqueous environments (see figure, color) and shows excellent agreement with atomic force microscopy images (figure, black) of the same aggregates.

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