• Open Access

MQD—Multiplex-Quadrature Detection in Multi-Dimensional NMR

Authors

  • Judith Schlagnitweit,

    1. Institute of Organic Chemistry, Johannes Kepler University Linz, Altenberger Str. 69, 4040 Linz (Austria), Fax: (+43) 732 2468 8747
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  • Michaela Horničáková,

    1. Institute of Organic Chemistry, Johannes Kepler University Linz, Altenberger Str. 69, 4040 Linz (Austria), Fax: (+43) 732 2468 8747
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  • Dr. Gerhard Zuckerstätter,

    1. Kompetenzzentrum Holz GmbH, Science Park, Bauteil 2, 2. Stock, Altenberger Straße 69, 4040 Linz (Austria)
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  • Prof. Norbert Müller

    Corresponding author
    1. Institute of Organic Chemistry, Johannes Kepler University Linz, Altenberger Str. 69, 4040 Linz (Austria), Fax: (+43) 732 2468 8747
    • Institute of Organic Chemistry, Johannes Kepler University Linz, Altenberger Str. 69, 4040 Linz (Austria), Fax: (+43) 732 2468 8747
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Abstract

With multiplex-quadrature detection (MQD) the tasks of coherence selection and quadrature separation in N-dimensional heteronuclear NMR experiments are merged. Thus the number of acquisitions required to achieve a desired resolution in the indirect dimensions is significantly reduced. The minimum number of transients per indirect data point, which have to be combined to give pure-phase spectra, is thus decreased by a factor (3/4)N−1. This reduction is achieved without adjustable parameters. We demonstrate the advantage by MQD 3D HNCO and HCCH-TOCSY spectra affording the same resolution and the same per-scan sensitivity as standard phase-cycled ones, but obtained in only 56 % of the usual time and by resolution improvements achieved in the same amount of time.

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