Get access

Magnetite Nanocrystal Clusters with Ultra-High Sensitivity in Magnetic Resonance Imaging

Authors

  • Dr. Fangjie Xu,

    1. School of Biomedical Engineering and Med-X Research Institute, Huashan Road Shanghai Jiaotong University, 200030 (China), Fax: (+86) 21-62933743
    Search for more papers by this author
  • Dr. Changming Cheng,

    1. School of Biomedical Engineering and Med-X Research Institute, Huashan Road Shanghai Jiaotong University, 200030 (China), Fax: (+86) 21-62933743
    Search for more papers by this author
  • Prof. Du-Xing Chen,

    1. ICREA and Departament de Física, Universitat Autònoma de Barcelona, 08193 Bellaterra (Spain)
    Search for more papers by this author
  • Prof. Hongchen Gu

    Corresponding author
    1. School of Biomedical Engineering and Med-X Research Institute, Huashan Road Shanghai Jiaotong University, 200030 (China), Fax: (+86) 21-62933743
    • School of Biomedical Engineering and Med-X Research Institute, Huashan Road Shanghai Jiaotong University, 200030 (China), Fax: (+86) 21-62933743
    Search for more papers by this author

Errata

This article is corrected by:

  1. Errata: Corrigendum: Magnetite Nanocrystal Clusters with Ultra-High Sensitivity in Magnetic Resonance Imaging Volume 13, Issue 6, 1377, Article first published online: 16 April 2012

Abstract

Magnetic iron oxide particles are widely used as contrast agents to improve the sensitivity of magnetic resonance imaging (MRI). Their efficiency in MRI is usually quantified by transverse relaxivity (r2) in solution. Herein, we synthesized a series of magnetite nanocrystal clusters (MNCs) with ultra-high transverse relaxivity by a polyol process and studied the relationship between r2 and size of the MNCs. The sizes of MNCs can be tuned over a wide range from 13 to 179 nm. The r2 of MNC suspensions as a function of the size of the cluster was analyzed and compared with a theoretical model. We found that MNCs of 64 nm had an r2 value of 650 mM−1 s−1, which was more than three times that of the commercial contrast agent and was among the highest reported for iron oxide materials. Compared with the theoretical model, the r2 value of the MNC suspension is approximately 0.93 of the theoretical prediction. Imaging of the MNC suspensions was performed in a clinical 1.5 T MRI instrument and a comparison was made between MNCs and commercial contrast agents. MRI indicated that the decrease of signal intensity induced by MNCs was in proportion to the r2 value, which was in accordance with theoretical predictions. These results demonstrate that MNCs with ultra-high transverse relaxivity and tunable size are promising candidates for molecular imaging and clinical diagnosis in MRI.

Ancillary