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Keywords:

  • biophysics;
  • hydrogen bonds;
  • Langmuir monolayers;
  • medicinal chemistry;
  • membranes
Thumbnail image of graphical abstract

New moiety for drug design: The chemical group squaramide shows promising results in medicinal chemistry. The mechanism of action of cyclic oligosquaramides at biological membranes is revealed by a monolayer study. The biological activity is related to the hydrophobicity of the new squaramide-derivative drugs.