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Mechanism of Action of Cyclic Oligosquaramides on DPPC Phospholipid Monolayers

Authors

  • Dr. Juan J. Giner-Casares,

    Corresponding author
    1. Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, Am Mühlenberg 1, 14476 Potsdam (Germany), Fax: (+49) 331567-7875
    2. Departamento de Química Física y Termodinámica Aplicada, Universidad de Córdoba, 14014 Córdoba (Spain)
    • Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, Am Mühlenberg 1, 14476 Potsdam (Germany), Fax: (+49) 331567-7875
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  • Janos Keller,

    1. Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, Am Mühlenberg 1, 14476 Potsdam (Germany), Fax: (+49) 331567-7875
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  • Dr. Carmen Rotger,

    1. Departament de Química, Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, 07122 Palma de Mallorca (Spain)
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  • Prof. Dr. Antoni Costa,

    1. Departament de Química, Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, 07122 Palma de Mallorca (Spain)
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  • Prof. Dr. Gerald Brezesinski

    1. Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, Am Mühlenberg 1, 14476 Potsdam (Germany), Fax: (+49) 331567-7875
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  • DPPC: 1,2-Dipalmitoylphosphatidylcholine

Abstract

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New moiety for drug design: The chemical group squaramide shows promising results in medicinal chemistry. The mechanism of action of cyclic oligosquaramides at biological membranes is revealed by a monolayer study. The biological activity is related to the hydrophobicity of the new squaramide-derivative drugs.

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