Communication

Different Mechanisms for Nanoparticle Formation between pDNA and siRNA Using Polyrotaxane as the Polycation

  1. Dr. Yuma Yamada1,
  2. Masahiro Hashida1,
  3. Taku Nomura1,
  4. Prof. Hideyoshi Harashima1,*,
  5. Dr. Yuichi Yamasaki2,
  6. Prof. Kazunori Kataoka2,
  7. Dr. Atsushi Yamashita3,5,
  8. Dr. Ryo Katoono3,
  9. Prof. Nobuhiko Yui4,*

Article first published online: 1 MAR 2012

DOI: 10.1002/cphc.201100800

Issue

ChemPhysChem

ChemPhysChem

Volume 13, Issue 5, pages 1161–1165, April 10, 2012

Additional Information

How to Cite

Yamada, Y., Hashida, M., Nomura, T., Harashima, H., Yamasaki, Y., Kataoka, K., Yamashita, A., Katoono, R. and Yui, N. (2012), Different Mechanisms for Nanoparticle Formation between pDNA and siRNA Using Polyrotaxane as the Polycation. ChemPhysChem, 13: 1161–1165. doi: 10.1002/cphc.201100800

Author Information

  1. 1

    Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812 (Japan), Fax: (+81) 11-706-4879

  2. 2

    Graduate School of Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan)

  3. 3

    School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292 (Japan)

  4. 4

    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10, Kanda-Surugadai, Chiyoda Tokyo 101-0062 (Japan)

  5. 5

    Current address: Institute of Bioengineering and Nanotechnology, 31 Biopolis way, The Nanos, #07-01, 138-669 (Singapore)

*Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812 (Japan), Fax: (+81) 11-706-4879

Publication History

  1. Issue published online: 29 MAR 2012
  2. Article first published online: 1 MAR 2012
  3. Manuscript Revised: 23 JAN 2012
  4. Manuscript Received: 11 OCT 2011

Funded by

  • Ministry of Education, Culture, Sports, Science and Technology
  • NIBIO

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Keywords:

  • DNA;
  • nanoparticles;
  • nucleic acids;
  • polymers;
  • RNA
Thumbnail image of graphical abstract

Ratios that matter: Investigations of nanoparticle formation using polyrotaxane as a polycation reveal that the formations of pDNA and siRNA nanoparticles with polycations are dependent on the nitrogen/phosphate ratio and the molar ratio, respectively.

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