Online Monitoring of Intelligent Polymers for Drug Release with Hyperpolarized Xenon

Authors

  • Stefan Glöggler,

    Corresponding author
    1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany), Fax: (+49) 241 8022185
    • Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany), Fax: (+49) 241 8022185
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  • Markus Raue,

    1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany), Fax: (+49) 241 8022185
    2. Institute for Applied Polymer Science, University of Applied Science Aachen, Heinrich-Mußmann-Straße 1, 52428 Jülich (Germany)
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  • Johannes Colell,

    1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany), Fax: (+49) 241 8022185
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  • Pierre Türschmann,

    1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany), Fax: (+49) 241 8022185
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  • Alexander Liebisch,

    1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany), Fax: (+49) 241 8022185
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  • Prof. Thomas Mang,

    1. Institute for Applied Polymer Science, University of Applied Science Aachen, Heinrich-Mußmann-Straße 1, 52428 Jülich (Germany)
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  • Prof. Bernhard Blümich,

    1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany), Fax: (+49) 241 8022185
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  • Prof. Stephan Appelt

    1. Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, 52074 Aachen (Germany), Fax: (+49) 241 8022185
    2. Central Institute for Electronics, Research Center Jülich, Wilhelm-Johnen-Straße, 52428 Jülich (Germany)
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Abstract

original image

Welcome to the guest zone: By combining hyperpolarized xenon and simple low-field NMR devices it is possible to obtain more control over hydrogels that show potential as drug delivery systems. An alternative way of polymer swelling-degree determination is demonstrated with real-time NMR analysis. An ideal region for solvent uptake can be defined in which the absorbed solvent molecules are completely confined in the nano-porous network of the hydrogel.

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