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Onset of Chiral Adenine Surface Growth

Authors

  • Dr. María Jose Capitán,

    1. Instituto de Estructura de la Materia-CSIC c/Serrano 119, 28006 Madrid (Spain)
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  • Dr. Jesús Álvarez,

    Corresponding author
    1. Departamento de Física de la Materia Condensada e Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid (Spain)
    • Departamento de Física de la Materia Condensada e Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid (Spain)
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  • Dr. Yang Wang,

    1. Departamento de Química, Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid (Spain)
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  • Dr. Roberto Otero,

    1. Departamento de Física de la Materia Condensada e Instituto Nicolás Cabrera, Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid (Spain)
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  • Dr. Manuel Alcamí,

    1. Departamento de Química, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid (Spain)
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  • Prof. Fernando Martín,

    1. Departamento de Química, Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid (Spain)
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  • Prof. Rodolfo Miranda

    1. Departamento de Física de la Materia Condensada e Instituto Nicolás Cabrera, Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid (Spain)
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Abstract

The structure and stability of adenine crystals and thin layers has been studied by using scanning tunneling microscopy, X-ray diffraction, and density functional theory calculations. We have found that adenine crystals can be grown in two phases that are energetically quasi-degenerate, the structure of which can be described as a pile-up of 2D adenine planes. In each plane, the structure can be described as an aggregation of adenine dimers. Under certain conditions, kinetic effects can favor the growth of the less stable phase. These results have been used to understand the growth of adenine thin films on gold under ultra-high vacuum conditions. We have found that the grown phase corresponds to the α-phase, which is composed of stacked prochiral planes. In this way, the adenine nanocrystals exhibit a surface that is enantiopure. These results could open new insight into the applications of adenine in biological, medical, and enantioselective or pharmaceutical fields.

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