Excimer Formation by Stacking G-Quadruplex Blocks

Authors

  • Dr. Nguyen Thuan Dao,

    1. School of Physical and Mathematical Science, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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  • Dr. Reinhard Haselsberger,

    1. School of Physical and Mathematical Science, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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  • Prof. Dr. Maria-Elisabeth Michel-Beyerle,

    Corresponding author
    1. School of Physical and Mathematical Science, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
    • School of Physical and Mathematical Science, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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  • Prof. Dr. Anh Tuân Phan

    Corresponding author
    1. School of Physical and Mathematical Science, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
    • School of Physical and Mathematical Science, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)
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Abstract

original image

A special stack: In the presence of K+ ions, a specific guanine-rich DNA sequence forms a stacked G-quadruplex dimer giving rise to excimer emission in the 400 nm region. This emission with nanosecond lifetime occurs only for a particular base overlap pattern between two stacked G-quadruplex blocks and can be manipulated by changing DNA sequence and external conditions.

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