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On the Nature of Interactions between Ionic Liquids and Small Amino-Acid-Based Biomolecules

Authors

  • Dr. Alesia A. Tietze,

    Corresponding author
    1. Technische Universität Darmstadt, Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry, Alarich-Weiss-Str. 4, 64287 Darmstadt, Fax.: +49 6151 16 72081
    • Technische Universität Darmstadt, Clemens-Schöpf-Institute for Organic Chemistry and Biochemistry, Alarich-Weiss-Str. 4, 64287 Darmstadt, Fax.: +49 6151 16 72081

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  • Prof. Dr. Frank Bordusa,

    1. Department of Natural Products Biochemistry, Institute of Biochemistry and Biotechnology, University of Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle (Germany)
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  • Dr. Ralf Giernoth,

    1. Chemistry Department, University of Cologne, Greinstr. 4, 50939 Köln (Germany)
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  • Prof. Dr. Diana Imhof,

    1. Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Brühler Str. 7, 53119 Bonn (Germany)
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  • Prof. Dr. Thomas Lenzer,

    1. Physical Chemistry, University of Siegen, Adolf-Reichwein-Str. 2, 57076 Siegen (Germany)
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  • Dr. Astrid Maaß,

    1. Department of Simulation Engineering, Computational Chemical Engineering, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, 53754 Sankt Augustin (Germany)
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  • Dr. Carmen Mrestani-Klaus,

    1. Department of Natural Products Biochemistry, Institute of Biochemistry and Biotechnology, University of Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120 Halle (Germany)
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  • Prof. Dr. Ines Neundorf,

    1. Institute of Biochemistry, Department of Chemistry, University of Cologne, Zülpicher Str. 47, 50674 Köln (Germany)
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  • Dr. Kawon Oum,

    1. Physical Chemistry, University of Siegen, Adolf-Reichwein-Str. 2, 57076 Siegen (Germany)
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  • Prof. Dr. Dirk Reith,

    1. Department of Simulation Engineering, Computational Chemical Engineering, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, 53754 Sankt Augustin (Germany)
    2. Department of Electrical/Mechanical Engineering and Tech. Journalism, Bonn-Rhein-Sieg University of Applied Sciences, Grantham-Allee 20, 53757 Sankt Augustin (Germany)
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  • Dr. Annegret Stark

    1. Institute of Chemical Technology, Universität Leipzig, Linnéstr. 3–4, 04103 Leipzig (Germany)
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Abstract

During the last decade, ionic liquids (ILs) have revealed promising properties and applications in many research fields, including biotechnology and biological sciences. The focus of this contribution is to give a critical review of the phenomena observed and current knowledge of the interactions occurring on a molecular basis. As opposed to the huge advances made in understanding the properties of proteins in ILs, complementary investigations dealing with interactions between ILs and peptides or oligopeptides are underrepresented and are mostly only of phenomenological nature. However, the field has received more attention in the last few years. This Review features a meta-analysis of the available data and findings and should, therefore, provide a basis for a scientifically profound understanding of the nature and mechanisms of interactions between ILs and structured or nonstructured peptides. Fundamental aspects of the interactions between different peptides/oligopeptides and ILs are complemented by sections on the experimental (spectroscopy, structural biology) and theoretical (computational chemistry) possibilities to explain the phenomena reported so far in the literature. In effect, this should lead to the development of novel applications and support the understanding of IL–solute interactions in general.

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