SEARCH

SEARCH BY CITATION

Keywords:

  • adhesion force;
  • atomic force microscopy;
  • fibrous proteins;
  • hydrophobic effect;
  • protein engineering
Thumbnail image of graphical abstract

Structure transition cascade: Insulin fibrils undergo a secondary structural transition—from the α-rich to the β-rich form—upon progressively increasing the incubation time from 0.5 to ten hours. Atomic force microscopy measurements show that the fibril surface chemistry changes from hydrophilic to hydrophobic and the aggregation rate increases fivefold.