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Effect of the Surface Chemistry of Insulin Fibrils on the Aggregation Rate

Authors

  • Prof. Shuchen Hsieh,

    Corresponding author
    1. Department of Chemistry, National Sun Yat-sen University, 70 Lien-hai Rd., Kaohsiung, Taiwan 80424 (Republic of China)
    2. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan 80708 (Republic of China)
    • Department of Chemistry, National Sun Yat-sen University, 70 Lien-hai Rd., Kaohsiung, Taiwan 80424 (Republic of China)

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  • Chiung-Wen Hsieh,

    1. Department of Chemistry, National Sun Yat-sen University, 70 Lien-hai Rd., Kaohsiung, Taiwan 80424 (Republic of China)
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  • Hsuan-Hung Chou,

    1. Department of Chemistry, National Sun Yat-sen University, 70 Lien-hai Rd., Kaohsiung, Taiwan 80424 (Republic of China)
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  • Chiung-Wen Chang,

    1. Department of Chemistry, National Sun Yat-sen University, 70 Lien-hai Rd., Kaohsiung, Taiwan 80424 (Republic of China)
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  • Ling-Ya Chu

    1. Department of Chemistry, National Sun Yat-sen University, 70 Lien-hai Rd., Kaohsiung, Taiwan 80424 (Republic of China)
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Abstract

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Structure transition cascade: Insulin fibrils undergo a secondary structural transition—from the α-rich to the β-rich form—upon progressively increasing the incubation time from 0.5 to ten hours. Atomic force microscopy measurements show that the fibril surface chemistry changes from hydrophilic to hydrophobic and the aggregation rate increases fivefold.

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