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Label-Free Biosensing over a Wide Concentration Range with Photonic Force Microscopy

Authors

  • Seungjin Heo,

    1. Graduate School of Nanoscience & Technology (WCU), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea)
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  • Prof. Kipom Kim,

    Corresponding author
    1. Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea)
    • Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea)===

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  • Prof. Yong-Hoon Cho

    Corresponding author
    1. Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea)
    2. Graduate School of Nanoscience & Technology (WCU), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea)
    3. Graphene Research Center, KAIST Institute for the NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea)
    • Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea)===

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Abstract

We present a label-free biosensor that measures molecular interactions between biomolecules on the surface of a probe bead and substrate over a wide concentration range. This system is capable of detecting target biomolecules with concentrations varying from 10 nM to 0.1 pM, with high selectivity and sensitivity.

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