Self-Propelled Janus Mesoporous Silica Nanomotors with Sub-100 nm Diameters for Drug Encapsulation and Delivery

Authors

  • Mingjun Xuan,

    1. State Key Lab of Urban Water Resource and Environment, Micro/Nanotechnology Research Centre, Harbin Institute of Technology, Harbin 150080 (P.R. China)
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  • Jingxin Shao,

    1. State Key Lab of Urban Water Resource and Environment, Micro/Nanotechnology Research Centre, Harbin Institute of Technology, Harbin 150080 (P.R. China)
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  • Dr. Xiankun Lin,

    1. State Key Lab of Urban Water Resource and Environment, Micro/Nanotechnology Research Centre, Harbin Institute of Technology, Harbin 150080 (P.R. China)
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  • Dr. Luru Dai,

    Corresponding author
    1. CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190 (P.R. China)
    • Luru Dai, CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190 (P.R. China)===

      Qiang He, State Key Lab of Urban Water Resource and Environment, Micro/Nanotechnology Research Centre, Harbin Institute of Technology, Harbin 150080 (P.R. China)===

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  • Prof. Qiang He

    Corresponding author
    1. State Key Lab of Urban Water Resource and Environment, Micro/Nanotechnology Research Centre, Harbin Institute of Technology, Harbin 150080 (P.R. China)
    • Luru Dai, CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190 (P.R. China)===

      Qiang He, State Key Lab of Urban Water Resource and Environment, Micro/Nanotechnology Research Centre, Harbin Institute of Technology, Harbin 150080 (P.R. China)===

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Abstract

The synthesis of an innovative self-propelled Janus nanomotor with a diameter of about 75 nm that can be used as a drug carrier is described. The Janus nanomotor is based on mesoporous silica nanoparticles (MSNs) with chromium/platinum metallic caps and propelled by decomposing hydrogen peroxide to generate oxygen as a driving force with speeds up to 20.2 μm s−1 (about 267 body lengths per second). The diffusion coefficient (D) of nanomotors with different H2O2 concentrations is calculated by tracking the movement of individual particles recorded by means of a self-assembled fluorescence microscope and is significantly larger than free Brownian motion. The traction of a single Janus MSN nanomotor is estimated to be about 13.47×10−15 N. Finally, intracellular localization and drug release in vitro shows that the amount of Janus MSN nanomotors entering the cells is more than MSNs with same culture time and particle concentrations, meanwhile anticancer drug doxorubicin hydrochloride loaded in Janus MSNs can be slowly released by biodegradation of lipid bilayers in cells.

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