This manuscript presents a brief overview of recent advances in multistimuli-responsive supramolecular gels (MRSGs). The synthesis of MRSGs with faster and smarter responsive abilities to a variety of external stimuli, such as redox reagents, pH changes, ligands, and coupling reagents, is one key issue for the upgrade of current molecular motors, signal sensors, shape memory devices, drug delivery systems, display devices, and other devices. However, the design rules of MRSGs are still not well understood. The lack of information about the relationship between the spatial structure and gelation behavior of existing gelators means that the knowledge required to design new gelators by the addition of functional moieties to well-known gelators is lacking. Insights into the gelation pathway of known gelators may bring inspiration to researchers who want to exploit elegant designs and specific building blocks to obtain their own MRSGs with predictable stimuli-responsive abilities.