Determining the Zero-Force Binding Energetics of an Intercalated DNA Complex by a Single-Molecule Approach (pages 2791–2794)
Tzu-Sen Yang, Yujia Cui, Chien-Ming Wu, Jem-Mau Lo, Chi-Shiun Chiang, Wun-Yi Shu, Wei-Ju Chung, Chung-Shan Yu, Kuo-Ning Chiang and Ian C. Hsu
Article first published online: 30 SEP 2009 | DOI: 10.1002/cphc.200900435
Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.