Very Low Energy Electrons Transform the Cyclobutane-Pyrimidine Dimer into a Highly Reactive Intermediate (pages 561–564)
Achim Edtbauer, Stephan Denifl, Violaine Vizcaino, Lukas An der Lan, Katherine Russell, Jörg Taubitz, Uta Wille, Linda Feketeova, Richard A. J. O'Hair, Tilmann D. Märk, Eugen Illenberger and Paul Scheier
Version of Record online: 23 DEC 2009 | DOI: 10.1002/cphc.200900912
Explosive reactions: The response of cytotoxic cyclobutane-pyrimidine dimer (CPD), a cross-linked pyrimidine base, to the attachment of a low-energy electron is remarkably similar to explosives like trinitrotoluene. The dominant unimolecular reaction is the splitting into two thymine like units, which is the essential molecular step in the photolyase of CPD (see picture).