Real-time Amyloid Aggregation Monitoring with a Photonic Crystal-based Approach (pages 3476–3482)
Sara Santi, Dr. Valeria Musi, Dr. Emiliano Descrovi, Dr. Vincent Paeder, Joab Di Francesco, Dr. Lubos Hvozdara, Dr. Peter van der Wal, Prof. Hilal A. Lashuel, Prof. Annalisa Pastore, Prof. Reinhard Neier and Prof. Hans Peter Herzig
Article first published online: 17 SEP 2013 | DOI: 10.1002/cphc.201300633
Catching the wave: A Bloch surface wave (BSW) is generated at the interface between a dielectric multilayer structure and a solution containing the Aβ(1-42) peptide. The BSW is sensitive to the variation of the refractive index (Δn) of the solution. This variation is related to conformational changes of the Aβ(1-42) peptide during aggregation, that is, the transition from an initial soluble form to a non-soluble fibrillar state (see figure).