Pulmonary Vascular Disease Related to Hemodynamic Stress in the Pulmonary Circulation
Published Online: 1 NOV 2010
Copyright © 2011 American Physiological Society. All rights reserved.
How to Cite
Chan, S. Y. and Loscalzo, J. 2010. Pulmonary Vascular Disease Related to Hemodynamic Stress in the Pulmonary Circulation. Comprehensive Physiology. 1:123–139.
- Published Online: 1 NOV 2010
Hemodynamic stress in the pulmonary vessel is directly linked to the development of vascular remodeling and dysfunction, ultimately leading to pulmonary hypertension. Recently, some advances have been made in our molecular understanding of the exogenous upstream stimuli that initiate hemodynamic pertubations as well as the downstream vasoactive effectors that control these responses. However, much still remains unknown regarding how these complex signaling pathways connect in order to result in these characteristic pathophysiological changes. This chapter will describe our current understanding of and needed areas of research into the clinical, physiological, and molecular changes associated with pressure/volume overload in the pulmonary circulation. © 2011 American Physiological Society. Compr Physiol 1:123-139, 2011.