Standard Article

Effects of Anesthetics, Sedatives, and Opioids on Ventilatory Control

  1. Eckehard A.E. Stuth,
  2. Astrid G. Stucke,
  3. Edward J. Zuperku

Published Online: 1 OCT 2012

DOI: 10.1002/cphy.c100061

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Stuth, E. A., Stucke, A. G. and Zuperku, E. J. 2012. Effects of Anesthetics, Sedatives, and Opioids on Ventilatory Control. Comprehensive Physiology. 2:2281–2367.

Author Information

  1. Medical College of Wisconsin, Anesthesia Research Service, Zablocki VA Medical Center, Milwaukee, Wisconsin

Publication History

  1. Published Online: 1 OCT 2012

Abstract

This article provides a comprehensive, up to date summary of the effects of volatile, gaseous, and intravenous anesthetics and opioid agonists on ventilatory control. Emphasis is placed on data from human studies. Further mechanistic insights are provided by in vivo and in vitro data from other mammalian species. The focus is on the effects of clinically relevant agonist concentrations and studies using pharmacological, that is, supraclinical agonist concentrations are de-emphasized or excluded. © 2012 American Physiological Society. Compr Physiol 2:2281-2367, 2012.