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Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body

  1. Prem Kumar1,
  2. Nanduri R. Prabhakar2

Published Online: 1 JAN 2012

DOI: 10.1002/cphy.c100069

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Kumar, P. and Prabhakar, N. R. 2012. Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body. Comprehensive Physiology. 2:141–219.

Author Information

  1. 1

    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom

  2. 2

    Institute for Integrative Physiology and Center for Systems Biology of Oxygen Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois

Publication History

  1. Published Online: 1 JAN 2012


The discovery of the sensory nature of the carotid body dates back to the beginning of the 20th century. Following these seminal discoveries, research into carotid body mechanisms moved forward progressively through the 20th century, with many descriptions of the ultrastructure of the organ and stimulus-response measurements at the level of the whole organ. The later part of 20th century witnessed the first descriptions of the cellular responses and electrophysiology of isolated and cultured type I and type II cells, and there now exist a number of testable hypotheses of chemotransduction. The goal of this article is to provide a comprehensive review of current concepts on sensory transduction and transmission of the hypoxic stimulus at the carotid body with an emphasis on integrating cellular mechanisms with the whole organ responses and highlighting the gaps or discrepancies in our knowledge. It is increasingly evident that in addition to hypoxia, the carotid body responds to a wide variety of blood-borne stimuli, including reduced glucose and immune-related cytokines and we therefore also consider the evidence for a polymodal function of the carotid body and its implications. It is clear that the sensory function of the carotid body exhibits considerable plasticity in response to the chronic perturbations in environmental O2 that is associated with many physiological and pathological conditions. The mechanisms and consequences of carotid body plasticity in health and disease are discussed in the final sections of this article. © 2012 American Physiological Society. Compr Physiol 2:141-219, 2012.