Standard Article

Chloride Transport

  1. John C. Edwards

Published Online: 1 APR 2012

DOI: 10.1002/cphy.c110027

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Edwards, J. C. 2012. Chloride Transport. Comprehensive Physiology. 2:1061–1092.

Author Information

  1. UNC Kidney Center and the Departments of Medicine and Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Publication History

  1. Published Online: 1 APR 2012


Chloride transport along the nephron is one of the key actions of the kidney that regulates extracellular volume and blood pressure. To maintain steady state, the kidney needs to reabsorb the vast majority of the filtered load of chloride. This is accomplished by the integrated function of sequential chloride transport activities along the nephron. The detailed mechanisms of transport in each segment generate unique patterns of interactions between chloride and numerous other individual components that are transported by the kidney. Consequently, chloride transport is inextricably intertwined with that of sodium, potassium, protons, calcium, and water. These interactions not only allow for exquisitely precise regulation but also determine the particular patterns in which the system can fail in disease states. © 2012 American Physiological Society. Compr Physiol 2:1061-1092, 2012.