Standard Article

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

  1. Christian K. Roberts1,
  2. Andrea L. Hevener2,
  3. R. James Barnard3

Published Online: 1 JAN 2013

DOI: 10.1002/cphy.c110062

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Roberts, C. K., Hevener, A. L. and Barnard, R. J. 2013. Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training. Comprehensive Physiology. 3:1–58.

Author Information

  1. 1

    Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing, University of California at Los Angeles, Los Angeles, California

  2. 2

    Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California

  3. 3

    Department of Integrative Biology and Physiology, University of California at Los Angeles, Los Angeles, California, Los Angeles, California

Publication History

  1. Published Online: 1 JAN 2013

Abstract

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia. Although there has been significant debate regarding the criteria and concept of the syndrome, this clustering of risk factors is unequivocally linked to an increased risk of developing type 2 diabetes and cardiovascular disease. Regardless of the true definition, based on current population estimates, nearly 100 million have MS. It is often characterized by insulin resistance, which some have suggested is a major underpinning link between physical inactivity and MS. The purpose of this review is to: (i) provide an overview of the history, causes and clinical aspects of MS, (ii) review the molecular mechanisms of insulin action and the causes of insulin resistance, and (iii) discuss the epidemiological and intervention data on the effects of exercise on MS and insulin sensitivity. © 2013 American Physiological Society. Compr Physiol 3:1-58, 2013.