Characterization and Regulation of Mechanical Loading-Induced Compensatory Muscle Hypertrophy
Published Online: 1 OCT 2012
Copyright © 2012 American Physiological Society. All rights reserved.
How to Cite
Adams, G. R. and Bamman, M. M. 2012. Characterization and Regulation of Mechanical Loading-Induced Compensatory Muscle Hypertrophy. Comprehensive Physiology. 2:2829–2870.
- Published Online: 1 OCT 2012
In mammalian systems, skeletal muscle exists in a dynamic state that monitors and regulates the physiological investment in muscle size to meet the current level of functional demand. This review attempts to consolidate current knowledge concerning development of the compensatory hypertrophy that occurs in response to a sustained increase in the mechanical loading of skeletal muscle. Topics covered include: defining and measuring compensatory hypertrophy, experimental models, loading stimulus parameters, acute responses to increased loading, hyperplasia, myofiber-type adaptations, the involvement of satellite cells, mRNA translational control, mechanotransduction, and endocrinology. The authors conclude with their impressions of current knowledge gaps in the field that are ripe for future study. © 2012 American Physiological Society. Compr Physiol 2:2829-2870, 2012.