Standard Article

Molecular Mechanism of TRP Channels

  1. Jie Zheng

Published Online: 1 JAN 2013

DOI: 10.1002/cphy.c120001

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Zheng, J. 2013. Molecular Mechanism of TRP Channels. Comprehensive Physiology. 3:221–242.

Author Information

  1. Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, California

Publication History

  1. Published Online: 1 JAN 2013


Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of physical and chemical stimuli. They are involved in the formation of sight, hearing, touch, smell, taste, temperature, and pain sensation. TRP channels also play fundamental roles in cell signaling and allow the host cell to respond to benign or harmful environmental changes. As TRP channel activation is controlled by very diverse processes and, in many cases, exhibits complex polymodal properties, understanding how each TRP channel responds to its unique forms of activation energy is both crucial and challenging. The past two decades witnessed significant advances in understanding the molecular mechanisms that underlie TRP channels activation. This review focuses on our current understanding of the molecular determinants for TRP channel activation. © 2013 American Physiological Society. Compr Physiol 3:221-242, 2013.