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Calcium Signaling in the Liver

  1. Maria Jimena Amaya,
  2. Michael H. Nathanson

Published Online: 1 JAN 2013

DOI: 10.1002/cphy.c120013

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Amaya, M. J. and Nathanson, M. H. 2013. Calcium Signaling in the Liver. Comprehensive Physiology. 3:515–539.

Author Information

  1. Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut

Publication History

  1. Published Online: 1 JAN 2013


Intracellular free Ca2+ ([Ca2+]i) is a highly versatile second messenger that regulates a wide range of functions in every type of cell and tissue. To achieve this versatility, the Ca2+ signaling system operates in a variety of ways to regulate cellular processes that function over a wide dynamic range. This is particularly well exemplified for Ca2+ signals in the liver, which modulate diverse and specialized functions such as bile secretion, glucose metabolism, cell proliferation, and apoptosis. These Ca2+ signals are organized to control distinct cellular processes through tight spatial and temporal coordination of [Ca2+]i signals, both within and between cells. This article will review the machinery responsible for the formation of Ca2+ signals in the liver, the types of subcellular, cellular, and intercellular signals that occur, the physiological role of Ca2+ signaling in the liver, and the role of Ca2+ signaling in liver disease. © 2013 American Physiological Society. Compr Physiol 3:515-539, 2013.