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Biochemistry and Physiology of Serotonergic Transmission

Handbook of Physiology, The Nervous System, Cellular Biology of Neurons

  1. Michael D. Gershon

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp010116

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Gershon, M. D. 2011. Biochemistry and Physiology of Serotonergic Transmission. Comprehensive Physiology. 573–623.

Author Information

  1. Department of Anatomy, Columbia University College of Physicans and Surgeons, New York, New York

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Serotonin Biosynthesis
    • 1.1
      Introductory Overview
    • 1.2
      Decarboxylation
    • 1.3
      Hydroxylation
  • 2
    Regulation of Serotonin Biosynthesis
    • 2.1
      Introductory Overview
    • 2.2
      Availability of Precursor Tryptophan
    • 2.3
      Feedback Control of Serotonin Biosynthesis
    • 2.4
      Inhibition of Tryptophan Hydroxylase: Serotonin Depletion
    • 2.5
      Chlorinated Amphetamines
  • 3
    Serotonin Metabolism
    • 3.1
      Introductory Overview
    • 3.2
      Oxidative Deamination
    • 3.3
      Conjugation
    • 3.4
      O-Sulfation
    • 3.5
      N- and O-Methylation
    • 3.6
      Inactivation of Circulating Serotonin
    • 3.7
      Pineal Gland
  • 4
    Uptake of Serotonin
    • 4.1
      Introductory Overview
    • 4.2
      Specific Uptake
    • 4.3
      Inhibition of Serotonin Uptake
  • 5
    Localization of Serotonin
    • 5.1
      Methodological Considerations
    • 5.2
      Identification of Monoamines
    • 5.3
      Serotonin Neurons
    • 5.4
      Regeneration of Serotonin Neurons
  • 6
    Molluscs
  • 7
    Serotonin Receptors, Antagonists, and Synaptic Effects
    • 7.1
      Myenteric Plexus
    • 7.2
      Ponto-Geniculo-Occipital Waves
    • 7.3
      Serotonin Receptor Isolation
  • 8
    Conclusion