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Pain and Nociception

Handbook of Physiology, The Nervous System, Sensory Processes

  1. Edward R. Perl

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp010320

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Perl, E. R. 2011. Pain and Nociception. Comprehensive Physiology. 915–975.

Author Information

  1. Department of Physiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Concepts and Theories
  • 2
    Pain as A Physiological Reaction
  • 3
    Aberrant Pain
    • 3.1
      Inflammation and Hyperalgesia
    • 3.2
      Referred Pain
    • 3.3
      Pain Associated With Pathology of Nervous System
  • 4
    Primary Afferent Neurons
    • 4.1
      Afferent Fiber Size and Quality of Pain
    • 4.2
      Identity of Receptive Units
    • 4.3
      Noxious Stimulation of Low-Threshold Sense Organs
    • 4.4
      Relationship of Nociceptor Activity to Pain
    • 4.5
      Chemical Mediators
    • 4.6
      Central Terminations of Primary Afferent Fibers
  • 5
    Ascending Sensory Pathways
    • 5.1
      Defining Pathways for Pain Sensation
    • 5.2
      Selectively Nociceptive Neurons of Spinal Cord and Trigeminal Nuclei
    • 5.3
      Nonselectively Nociceptive Excitation
    • 5.4
      Origins of Spinothalamic and Related Systems
    • 5.5
      Functional Attributes of Neurons Projecting Over Ventral Quadrant Tracts
    • 5.6
      Projection Pathways for the Face
    • 5.7
      Other Ascending Pathways
    • 5.8
      Brain Stem, Hypothalamic, and Thalamic Components
    • 5.9
      Cerebral Cortex
  • 6
    Modulation of Nociceptive Neurons
    • 6.1
      Afferent Modulation
    • 6.2
      Descending Effects
    • 6.3
      Opiate Receptors, Opioids, and Endorphins
    • 6.4
      Cellular Mechanisms of Modulation
    • 6.5
      Higher Level Interactions
    • 6.6
      Functional Significance of Modulatory Mechanisms
  • 7
    Recapitulation