Standard Article

Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory

Handbook of Physiology, The Nervous System, Higher Functions of the Brain

  1. Patricia S. Goldman-Rakic

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp010509

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Goldman-Rakic, P. S. 2011. Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory. Comprehensive Physiology. 373–417.

Author Information

  1. Yale University School of Medicine, New Haven, Connecticut

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Essence of Prefrontal Function: Regulation of Behavior by Representational Knowledge
    • 1.1
      Subdivisions of Prefrontal Cortex
    • 1.2
      Global Nature of Prefrontal Syndrome in Humans
    • 1.3
      Animal Model for Prefrontal Function in Humans
    • 1.4
      Delayed-Response Tests and Varying Interpretations of Their Functional Significance
    • 1.5
      Distractability and Perseveration: Secondary Consequences of Basic Defect in Representational Memory
    • 1.6
      Representational Memory in Wisconsin Card Sort and Other Diagnostic Tests of Prefrontal Function in Humans
    • 1.7
      Localization of Delayed-Response Function: Principal Sulcus
    • 1.8
      Circuit Basis of Visuospatial Functions
  • 2
    Accessing and “On-Line” Processing of Representations in Visuospatial Domain: Parietal-Prefrontal Connections
    • 2.1
      Visuospatial Representational Memory in Humans
    • 2.2
      Spatial-Mnemonic Nature of Delayed-Response Deficit: Domain-Specific Memory Loss
    • 2.3
      Topography of Representational Memory in Prefrontal Cortex
    • 2.4
      Electrophysiological Evidence of Spatial-Mnemonic Processes in Principal Sulcus
    • 2.5
      Parietal-Prefrontal Connectivity
    • 2.6
      Columnar and Laminar Framework for Feedforward and Feedback Mechanisms
    • 2.7
      Functional Significance of Parietal-Prefrontal Collaboration
  • 3
    Long-Term Memory and “Off-Line” Processing: Prefrontal-Limbic Connections
    • 3.1
      Role of Hippocampus in Spatial Memory
    • 3.2
      Multiple Connections Between Principal Sulcus and Hippocampal Formation
    • 3.3
      Quadripartite Neural Network: Parietal-Temporal-Cingulate-Prefrontal Circuit
    • 3.4
      Limbic Contribution to Spatial Memory
  • 4
    Response Initiation and Inhibition: Projections to Striatum, Tectum, Thalamus, and Premotor Cortex
    • 4.1
      Motor-Control Functions of Prefrontal Cortex
    • 4.2
      Cortical-Striatal Pathway and Related Feedback Loops
    • 4.3
      Cortical-Tectal Pathway
    • 4.4
      Thalamic-Cortical Systems
    • 4.5
      Prefrontal-Premotor Connections: Anterior Supplementary Motor Cortex Relays
    • 4.6
      Functional Speculations
  • 5
    Modulatory Mechanisms: Brain Stem Catecholamine Projections
    • 5.1
      Activation of Cognitive Machinery
    • 5.2
      Concentration and Synthesis of Catecholamines in Primate Cortex
    • 5.3
      Brain Stem Innervation of Prefrontal Cortex
    • 5.4
      Delayed-Response Deficits and Recovery Produced by Catecholamine Loss and Replacement in Prefrontal Cortex
    • 5.5
      Circuit Basis for Neuromodulation in Principal Sulcus
  • 6
    Multiple Subsystems of Prefrontal Cortex: Unity or Diversity of Function
    • 6.1
      Unity or Diversity of Prefrontal Function
    • 6.2
      Frontal Eye Fields
    • 6.3
      Inferior Convexity
    • 6.4
      Orbital Prefrontal Cortices
    • 6.5
      Problem of Integration
  • 7
    Diseases Affecting Prefrontal Cortex
    • 7.1
      Schizophrenia: Loss of Corticocortical Processing and Regulation of Behavior by Representational Knowledge
    • 7.2
      Wernicke-Korsakoff Syndrome: Loss of Thalamocortical and Brain Stem Modulatory Mechanisms
    • 7.3
      Huntington's Chorea and Parkinson's Disease: Loss of Prefrontal-Striatal Mechanisms and Initiation or Inhibition of Motor Response
    • 7.4
      Overview of Neurobiology of Disease
  • 8
    Summary