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Gap Junctions in the Cardiovascular System

Handbook of Physiology, The Cardiovascular System, The Heart

  1. David C. Spray1,
  2. Sylvia O. Suadicani2,3,
  3. Miduturu Srinivas4,
  4. David E. Gutstein5,
  5. Glenn I. Fishman6

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp020104

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Spray, D. C., Suadicani, S. O., Srinivas, M., Gutstein, D. E. and Fishman, G. I. 2011. Gap Junctions in the Cardiovascular System. Comprehensive Physiology. 169–212.

Author Information

  1. 1

    Departments of Neuroscience and Medicine, Albert Einstein College of Medicine, Bronx, New York

  2. 2

    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York

  3. 3

    Universidade São Judas Tadeu, São Paulo, Brazil

  4. 4

    Department of Neuroscience. Albert Einstein College of Medicine, Bronx, New York

  5. 5

    Department of Medicine, Mount Sinai School of Medicine, New York, New York

  6. 6

    Departments of Medicine, Physiology and Biophysics, and Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Cardiovascular Gap Junction Proteins
    • 1.1
      Ultrastructural Features
    • 1.2
      Higher Resolution Through Projection Images
    • 1.3
      The Connexin Multigene Family
    • 1.4
      Connexin and Connexon Topology
    • 1.5
      Regional Connexin Expression in the Cardiovascular System
    • 1.6
      Why Are There Multiple Cardiovascular Connexins?
  • 2
    Macroscopic Organization of the Heart (Cables, Bricks, and Textures)
    • 2.1
      Gap Junction Organization within the Tissue
    • 2.2
      Modeling Tissue Connections
    • 2.3
      Optical Imaging of Patterned Cell Cultures
    • 2.4
      Microscopic and Macroscopic Discontinuities
  • 3
    Regulation of Gap Junction Expression, Formation, and Degradation
    • 3.1
      Life and Death of Gap Junctions
    • 3.2
      Long-Term Changes in Gap Junction Expression
    • 3.3
      Transcriptional Regulation of Cardiac Gap Junction Genes
  • 4
    Functional Properties of Cardiovascular Gap Junctions
    • 4.1
      Cardiovascular Gap Junctions Are K+, Ca2+, and Second Messenger Channels
    • 4.2
      Biophysical Properties of Junctional Channels
    • 4.3
      Gating of Gap Junctional Channels by Transjunctional Voltage
    • 4.4
      Properties of Specific Connexins Expressed in Exogenous Systems
    • 4.5
      Properties of Gap Junctions Evaluated in Cardiovascular Cells
    • 4.6
      Gating of Gap Junctions by Other Stimuli
  • 5
    Genetic and Somatic Disease States in Which Gap Junction Expression or Function is Altered
    • 5.1
      Somatic Cardiac Abnormalities
    • 5.2
      Reversed Physiology: Inferring Gene Function from Its Absence in Knockout Mice