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Cardiac Sarcoplasmic Reticulum Ca2+-ATPase

Handbook of Physiology, The Cardiovascular System, The Heart

  1. Michihiko Tada,
  2. Toshihiko Toyofuku

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp020108

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Tada, M. and Toyofuku, T. 2011. Cardiac Sarcoplasmic Reticulum Ca2+-ATPase. Comprehensive Physiology. 301–334.

Author Information

  1. Department of Medicine and Pathophysiology, Osaka University School of Medicine, Osaka, Japan

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Structure of the Ca2+-ATPase
    • 1.1
      Structure of Cardiac Sarcoplasmic Reticulum
    • 1.2
      Isolation and Characterization of Cardiac Sarcoplasmic Reticulum
  • 2
    Function of Ca2+-ATPase
    • 2.1
      Ca2+ Pumping Function
    • 2.2
      Mechanism of Ca2+-ATPase Activity
    • 2.3
      Regulation of Ca2+-ATPase Activity
  • 3
    Structure and Function of Ca2+-ATPase
    • 3.1
      Primary Sequences and Structural Models for Ca2+-ATPases
    • 3.2
      Chemical Modifications of the Ca2+-ATPase
    • 3.3
      Site-Directed Mutagenesis of Ca2+-ATPase
    • 3.4
      Ca2+-ATPase Isoform Chimeras
  • 4
    Regulation of Ca2+-ATPase by Phospholamban
    • 4.1
      Structure of Phospholamban
    • 4.2
      Function of Phospholamban
    • 4.3
      Interaction Between Ca2+-ATPase and Phospholamban
    • 4.4
      Physiological Relevance of Phospholamban-Ca2+-ATPase System
  • 5
    Regulation of Ca2+-ATPase and Phospholamban Genes
    • 5.1
      Structure of the Ca2+-ATPase Gene
    • 5.2
      Transcriptional Regulation of the Ca2+-ATPase Gene
    • 5.3
      Structure of the Phospholamban Gene
    • 5.4
      Transcriptional Regulation of the Phospholamban Gene