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Molecular Analysis of Voltage-Gated K+ Channel Diversity and Functioning in the Mammalian Heart

Handbook of Physiology, The Cardiovascular System, The Heart

  1. Jeanne M. Nerbonne

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp020115

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Nerbonne, J. M. 2011. Molecular Analysis of Voltage-Gated K+ Channel Diversity and Functioning in the Mammalian Heart. Comprehensive Physiology. 568–594.

Author Information

  1. Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Electrophysiological Diversity of Voltage-Gated Myocardial K+ Channel Currents
    • 1.1
      Transient Outward K+ Current Channels, Ito
    • 1.2
      Delayed Rectifier K+ Currents, IK
    • 1.3
      Cellular/Regional Heterogeneity in Voltage-Gated K+ Current Expression and Properties
  • 2
    Molecular Determinants of Voltage-Gated Cardiac K+ Channels
    • 2.1
      Voltage-Gated K+ Channel Pore-Forming α Subunits
    • 2.2
      Accessory Subunits of Voltage-Gated K+ Channels
    • 2.3
      Voltage-Gated K+ Channels and the Cytoskeleton
  • 3
    Molecular Correlates of Functional Voltage-Gated K+ Channels
    • 3.1
      Molecular Genetics of Cardiac Delayed Rectifier K+ Currents, IKr and IKs
    • 3.2
      Transgenic and Targeted Gene Deletion Approaches
    • 3.3
      Molecular Correlates of Other Voltage-Gated Cardiac K+ Currents
  • 4
    Functional Consequences of in Vivo Alterations in Voltage-Gated Myocardial K+ Channels
    • 4.1
      QT Prolongation
    • 4.2
      Atrioventricular Block
    • 4.3
      Ventricular Arrhythmia/Tachycardia
    • 4.4
      Pathophysiology
  • 5
    Summary, Conclusions, and Future Directions