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Intrinsic Prostaglandin Biosynthesis in Blood Vessels

Handbook of Physiology, The Cardiovascular System, Vascular Smooth Muscle

  1. Philip Needleman,
  2. Peter C. Isakson

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp020220

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Needleman, P. and Isakson, P. C. 2011. Intrinsic Prostaglandin Biosynthesis in Blood Vessels. Comprehensive Physiology. 613–633.

Author Information

  1. Department of Pharmacology, Washington University Medical School, St. Louis, Missouri

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Prostaglandin Synthesis and General Properties
    • 1.1
      Biosynthesis of Prostaglandins
    • 1.2
      Effects of Exogenous Prostaglandins on Vascular Smooth Muscle
    • 1.3
      Summary
  • 2
    Prostaglandins and the Mesenteric and Celiac Arteries
    • 2.1
      Intrinsic Vascular Synthesis of Prostaglandins
    • 2.2
      Influence of Local Vascular Prostaglandins on Neuronal Activity and Blood Vessel Tone
    • 2.3
      Differential PG Synthesis in Arteries and Veins
  • 3
    Prostaglandin Biosynthesis in the Ductus Arteriosus
  • 4
    Human Umbilical Artery
    • 4.1
      Intrinsic Prostaglandin Biosynthesis
    • 4.2
      Prostaglandin Synthesis in Blood Vessel Tissue Culture
  • 5
    Coronary Arteries
    • 5.1
      Contribution of Intrinsic Prostaglandins to Coronary Tone
    • 5.2
      Paradoxical Endogenous Synthesis of a Coronary Dilating Substance from Arachidonate
    • 5.3
      Effect of Prostaglandin Endoperoxides on Bovine Coronary Arteries
    • 5.4
      Novel Metabolic Arachidonate Pathway that Generates a Potent Endogenous Vasodilator
  • 6
    Prostacyclin
    • 6.1
      Arterial Synthesis of a Novel Prostaglandin that Inhibits Platelet Aggregation
    • 6.2
      Inhibition of the Vascular Synthesis of the Novel Prostaglandin
    • 6.3
      Intrinsic Vascular Synthesis of a Prostaglandin Vasodilator in Mesenteric, Celiac, and Coronary Arteries
    • 6.4
      Chemical Identification of Prostacyclin
    • 6.5
      Prostacyclin and Thromboxane A2 Characterization Criteria
  • 7
    Pathophysiological Significance of Vascular Prostacyclin Synthesis and its Pharmacological Modification