Standard Article

Protein Turnover in the Lungs

Handbook of Physiology, The Respiratory System, Circulation and Nonrespiratory Functions

  1. Donald Massaro

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp030107

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Massaro, D. 2011. Protein Turnover in the Lungs. Comprehensive Physiology. 277–308.

Author Information

  1. Veterans Administration and Pulmonary Division, University of Miami School of Medicine, Miami, Florida

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Protein Turnover in Nonpulmonary Tissues and Cells
  • 2
    Physiological Importance of Protein Turnover
  • 3
    Methods of Studying Protein Turnover in the Lung
  • 4
    Precursor Pools
  • 5
    Effect of Proteolysis on Extracellular Specific Radioactivity
  • 6
    Amino Acid Compartmentation in Perfused Lung
  • 7
    Protein Turnover Rates
  • 8
    Regulation of General Protein Turnover
    • 8.1
      Diet
    • 8.2
      Hormones
  • 9
    Degradation of General Lung Proteins
  • 10
    Regulation of Protein Degradation
    • 10.1
      Exogenous Amino Acids
    • 10.2
      Hypoxia
    • 10.3
      Interaction Between Exogenous Amino Acids and Hypoxia
    • 10.4
      Potential Physiological Importance of Interaction Between Amino Acids and Hypoxia
    • 10.5
      Glucose and Insulin
  • 11
    Connective Tissue Proteins of the Lung
    • 11.1
      Collagen
    • 11.2
      Elastin
  • 12
    Pulmonary Fibrosis
  • 13
    Proteases and Protease Inhibitors
  • 14
    Hyperoxia and Protein Synthesis
  • 15
    Protein Turnover in Pulmonary Macrophages
    • 15.1
      Choice of Precursor Amino Acid
    • 15.2
      Precursor Pools
    • 15.3
      Protein Degradation
    • 15.4
      Phagocytosis and Protein Turnover
    • 15.5
      Substrates and Protein Turnover
    • 15.6
      Other Factors Affecting Protein Turnover in Pulmonary Macrophages