Standard Article

Alveolar Surface Tension and Lung Surfactant

Handbook of Physiology, The Respiratory System, Mechanics of Breathing

  1. Jon Goerke,
  2. John A. Clements

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp030316

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Goerke, J. and Clements, J. A. 2011. Alveolar Surface Tension and Lung Surfactant. Comprehensive Physiology. 247–261.

Author Information

  1. Departments of Physiology and Pediatrics and the Cardiovascular Research Institute, University of California, San Francisco, California

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Background
    • 1.1
      Early Contributors
    • 1.2
      Relevance of Alveolar Surface Film
    • 1.3
      Current Model of Lung Surfactant Action
  • 2
    Definition and Measurement of Surface Tension
    • 2.1
      Generation of Interfacial Tension
    • 2.2
      Methods
  • 3
    Adsorption and Spreading of Surfactant Films
    • 3.1
      Form of Surfactant
    • 3.2
      Factors Affecting Adsorption and Spreading
  • 4
    Properties of Films Related to Lung Surfactant
    • 4.1
      Low Surface Tension and Other Quasi-Static Film Properties
    • 4.2
      Dynamic Film Properties
  • 5
    Influence of Surface Tension on Lung Pressure-Volume Behavior
    • 5.1
      Static Properties
    • 5.2
      Dynamic Properties
  • 6
    Turnover and Recycling of Surfactant Components
    • 6.1
      Possible Recycling Paths
    • 6.2
      Local Monolayer Recycling
    • 6.3
      Extramonolayer Recycling Pathways
  • 7
    Summary of Lung Surfactant Properties
    • 7.1
      Rapid Adsorption and Spreading
    • 7.2
      Low Surface Tension When Film is Compressed
    • 7.3
      Stable Low Surface Tension
  • 8
    Future Considerations