Standard Article

Diffusing-Capacity Heterogeneity

Handbook of Physiology, The Respiratory System, Gas Exchange

  1. Michael P. Hlastala

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp030412

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Hlastala, M. P. 2011. Diffusing-Capacity Heterogeneity. Comprehensive Physiology. 217–232.

Author Information

  1. Departments of Medicine and of Physiology and Biophysics, University of Washington, Seattle, Washington

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Gas Equilibration Across Alveolar-Capillary Membrane
  • 2
    Regional Diffusing-Capacity Heterogeneity
    • 2.1
      Theoretical Considerations
    • 2.2
      Experimental Evidence for Diffusing-Capacity Heterogeneity
    • 2.3
      Differential Effect of Diffusing-Capacity Heterogeneity on O2 and CO Transfer
    • 2.4
      Exercise
    • 2.5
      Pulmonary Capillary Transit Time
    • 2.6
      Vertical Distribution of Diffusing Capacity
    • 2.7
      Carrier-Gas Density
    • 2.8
      Comparison of Physiological and Morphological Measurements of Diffusing Capacity
  • 3
    Interaction of Ventilation-Perfusion Heterogeneity with Diffusing-Capacity Heterogeneity
  • 4
    Solubility Dependence of Gas Exchange
  • 5
    Molecular-Weight Dependence of Gas Exchange
  • 6
    Combined Solubility and Molecular-Weight Dependence
  • 7
    Future Directions