Standard Article

Tissue Capacity for Mitochondrial Oxidative Phosphorylation and its Adaptation to Stress

Handbook of Physiology, Environmental Physiology

  1. William L. Rumsey1,
  2. David F. Wilson2

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp040247

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Rumsey, W. L. and Wilson, D. F. 2011. Tissue Capacity for Mitochondrial Oxidative Phosphorylation and its Adaptation to Stress. Comprehensive Physiology. 1095–1113.

Author Information

  1. 1

    Department of Pharmacology, Zeneca Pharmaceuticals, Wilmington, Delaware

  2. 2

    Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia, Pennsylvania

Publication History

  1. Published Online: 1 JAN 2011


The sections in this article are:

  • 1
    Regulation of the Rate of Mitochondrial Oxidative Phosphorylation in Vivo
    • 1.1
      “Supply” and “Demand” in Determining the Mitochondrial Respiratory Rate
    • 1.2
      On the Mechanism of Regulation of Mitochondrial ATP Synthesis In Vivo
    • 1.3
      Oxygen Dependence of Mitochondrial Oxidative Phosphorylation In Vivo
  • 2
    Mitochondrial Enzyme Content in Cells with Different Rates of Respiration
  • 3
    Metabolic Adaptation of Heart Muscle to Alterations in Physiological Work Rate
  • 4
    Metabolic Adaptations of Skeletal Muscle in Response to Endurance Training and to Electrical Stimulation
    • 4.1
      General Observations
    • 4.2
      Effects of Increased Energy Demand on Enzyme Content and Metabolism of Skeletal Muscle
    • 4.3
      Enhancement of Protein Synthesis
    • 4.4
      Possible Second Messengers
    • 4.5
      Resistance to Fatigue During Exertion
  • 5
    Effects of Conditioning on the Capacity for Oxygen Delivery to Local Regions of the Muscle
    • 5.1
      Changes in Muscle Capillarity
    • 5.2
      Changes in Myoglobin Content
  • 6
    Evolutionary Design of Muscles for Different Work Loads
  • 7
    Effects of Deconditioning on the Activity of Oxidative Enzymes in Muscle
  • 8
    Effects of Chronic Diminished Substrate Delivery on Energy Metabolism in Muscle
    • 8.1
      Effect of Restricted Blood Flow in Muscle
    • 8.2
      High-Altitude Induced Adaptation
  • 9