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Pharmacology of drugs acting on gastrointestinal motility

Handbook of Physiology, The Gastrointestinal System, Motility and Circulation

  1. Edwin E. Daniel,
  2. Stephen M. Collins,
  3. Jo-Ann E. T. Fox,
  4. Jan D. Huizinga

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060119

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Daniel, E. E., Collins, S. M., Fox, J.-A. E. T. and Huizinga, J. D. 2011. Pharmacology of drugs acting on gastrointestinal motility. Comprehensive Physiology. 715–757.

Author Information

  1. Department of Neurosciences and Department of Medicine and School of Nursing, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Nature and Classification of Receptors
    • 1.1
      Basis of Classification
    • 1.2
      Functional Studies of Receptors
    • 1.3
      Ligand Binding Studies of Receptors
    • 1.4
      Problems in Locus, Classification, and Functional Coupling of Receptors
    • 1.5
      Methods of Quantitation of Drug-Receptor Responses
  • 2
    Agents that Act Directly on Postreceptor Mechanisms
  • 3
    Isolated Smooth Muscle Cell Preparations for Studying Pharmacology of Gastrointestinal Motility
  • 4
    Muscarinic Receptors
    • 4.1
      Muscarinic Receptor Subtypes
    • 4.2
      Locus of Action of Muscarinic Receptors
    • 4.3
      Modulation of Muscarinic Receptor
    • 4.4
      Muscarinic Postreceptor Events
    • 4.5
      Therapeutic Application of Muscarinic Pharmacology
  • 5
    Adrenergic Receptors and Gut Motility
    • 5.1
      Sympathetic Pathways
    • 5.2
      Functions of Adrenergic Innervation
    • 5.3
      Receptor Classification
    • 5.4
      Postreceptor Mechanisms
    • 5.5
      β-Adrenoceptor-Mediated Mechanisms
  • 6
    Serotonin Receptors and Gut Motility
    • 6.1
      Introduction
    • 6.2
      Locus and Function of Serotonin Nerves
    • 6.3
      Classification of Serotonin Receptors
    • 6.4
      Direct Action on Smooth Muscle
    • 6.5
      Actions of Serotonin on Enteric Nerves
    • 6.6
      Therapeutic Considerations
  • 7
    Purinergic Receptors and Gut Motility
    • 7.1
      Possible Functions of Purinergic Substances
    • 7.2
      Role of Purinergic Substances in Nonadrenergic Inhibition of Gut
    • 7.3
      Postsynaptic Activity
    • 7.4
      Presynaptic Activity
    • 7.5
      Classification
    • 7.6
      Mechanisms of Postsynaptic Activity