Standard Article

Cholecystokinin

Handbook of Physiology, The Gastrointestinal System, Neural and Endocrine Biology

  1. Jens F. Rehfeld

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060216

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Rehfeld, J. F. 2011. Cholecystokinin. Comprehensive Physiology. 337–358.

Author Information

  1. Department of Clinical Chemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Definition of Cholecystokinin
  • 2
    History of Cholecystokinin
    • 2.1
      Digestive Juice Era
    • 2.2
      Peptide Chemistry Era
    • 2.3
      Immunochemistry Era
    • 2.4
      Nucleotide Chemistry Era
  • 3
    Molecular Biology of Cholecystokinin
    • 3.1
      Cholecystokinin Gene and mRNA
    • 3.2
      Primary Translation Product, Prepro CCK
    • 3.3
      Posttranslational Processing
    • 3.4
      Structure of Bioactive Cholecystokinins
    • 3.5
      Homology With Other Hormones
  • 4
    Cellular Distribution of Cholecystokinin
    • 4.1
      Endocrine Cells in the Gut
    • 4.2
      Endocrine Cells Outside the Gut
    • 4.3
      Cholecystokinin Neurons in the Gut
    • 4.4
      Cholecystokinin Neurons Outside the Gut
  • 5
    Secretion of Cholecystokinin
    • 5.1
      Release From Endocrine Cells
    • 5.2
      Release from Neurons
  • 6
    Cholecystokinin in Plasma
    • 6.1
      Plasma Assays
    • 6.2
      Molecular Forms in Plasma
    • 6.3
      Concentrations in Basal and Stimulated State
  • 7
    Effect of Cholecystokinin
    • 7.1
      Cholecystokinin Receptors
    • 7.2
      Gallbladder Emptying and Bile Release
    • 7.3
      Pancreatic Exocrine Secretion
    • 7.4
      Pancreatic Endocrine Secretion
    • 7.5
      Pancreatic Growth
    • 7.6
      Gastrointestinal Motility
    • 7.7
      Intestinal Blood Flow
    • 7.8
      Satiety
  • 8
    Clinical Aspects of Cholecystokinin
    • 8.1
      Diagnostic Use
    • 8.2
      Therapeutic Use
    • 8.3
      Abnormalities
  • 9
    Conclusion