Standard Article

Somatostatin

Handbook of Physiology, The Gastrointestinal System, Neural and Endocrine Biology

  1. Tadataka Yamada,
  2. Tsutomu Chiba

Published Online: 1 JAN 2011

DOI: 10.1002/cphy.cp060219

Comprehensive Physiology

Comprehensive Physiology

How to Cite

Yamada, T. and Chiba, T. 2011. Somatostatin. Comprehensive Physiology. 431–453.

Author Information

  1. Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan

Publication History

  1. Published Online: 1 JAN 2011

Abstract

The sections in this article are:

  • 1
    Biochemistry of Somatostatin
    • 1.1
      Structure
    • 1.2
      Biosynthesis
  • 2
    Distribution of Somatostatin in the Gastrointestinal Tract
  • 3
    Radioimmunoassay of Somatostatin in Plasma
    • 3.1
      Assay Methods
    • 3.2
      Metabolic Clearance
  • 4
    Regulation of Somatostatin Release
    • 4.1
      Release by Intraluminal Stimuli
    • 4.2
      Release by Neurotransmitters and Peptides
    • 4.3
      Intracellular Mechanisms Governing Somatostatin Secretion
  • 5
    Actions of Somatostatin in the Gut
    • 5.1
      Gastric Function
    • 5.2
      Intestinal Absorption and Secretion
    • 5.3
      Gastrointestinal Motility
    • 5.4
      Miscellaneous Effects
    • 5.5
      Somatostatin Receptors
    • 5.6
      Intracellular Mechanisms of Somatostatin Action